Search on: HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED CHANNELS 
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Descriptor English:   Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels 
Descriptor Spanish:   Canales Regulados por Nucleótidos Cíclicos Activados por Hiperpolarización 
Descriptor Portuguese:   Canais Disparados por Nucleotídeos Cíclicos Ativados por Hiperpolarização 
Synonyms English:   Hyperpolarization Cyclic-Nucleotide Gated Ion Channels  
Tree Number:   D12.776.157.530.400.368
D12.776.543.550.425.476
D12.776.543.585.400.476
Definition English:   A subgroup of cyclic nucleotide-regulated ION CHANNELS of the superfamily of pore-loop cation channels that are opened by hyperpolarization rather than depolarization. The ion conducting pore passes SODIUM, CALCIUM, and POTASSIUM cations with a preference for potassium. 
History Note English:   2014 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification CT contraindications
DF deficiency DU diagnostic use
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   55318 
Unique Identifier:   D064428 

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